Today cancer stem cells in a wide variety of human tumors have been identified. Cancer stem cells have many challenges for human and on the other hand has great potential to add to the man in the fight against cancer. One area of emphasis will be intercellular communication. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system.

Today the cancer stem cells in a wide variety of human tumors have been identified. Cancer stem cells have many challenges for human and on the other hand has great potential to add to the man in the fight against cancer. One area of emphasis will be intercellular communication. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system. In addition, developmental signal transduction pathways such as Hippo, Notch and Wnt, frequently deregulated in cancer, increasingly offer tangible opportunities for therapeutic intervention. Another important area of emphasis will be efforts to better understand the mechanisms and importance of tumor heterogeneity. Techniques such as clonal analysis and barcoding are shedding important light on the interplay between tumor evolution, differentiation, miRNA control and epigenetics. This is an era of rapid progress in understanding cancer stem cell biology with great potential to benefit human health.

16:00—20:00

Arrival and Registration

18:00—20:00

Welcome Mixer

07:00—08:00

Breakfast

08:00—09:00

Welcome and Keynote Address

09:00—11:15

Stem Cell Concepts and Models

Registered attendees can view abstracts sending on 02/06/2019

Stability and reversibility of the stem cell state, lessons from model systems, comparisons with normal stem cells and self-renewal.

Jane E. Visvader, Walter and Eliza Hall Institute of Medical Research, Australia

Normal Mammary Stem Cells

Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai, USA

Modeling Myeloid Malignancies with Human Pluripotent Stem Cells

Ali Turhan, University Paris Sud 11, France

Modeling Cancer using Human iPSC

Short Talk(s) Chosen from Abstracts

09:40—10:00

Coffee Break

11:15—13:00

Poster Setup

13:00—22:00

Poster Viewing

16:30—17:00

Coffee Available

17:00—19:00

Intercellular Interactions: Non-Cell Autonomous CSC Biology

Registered attendees can view abstracts sending on 02/06/2019

Cooperativity, niche and immune interaction.

Carla F. Kim, Boston Children's Hospital, USA

Lung Cancer Stem Cells

Dominique A. Bonnet, Cancer Research UK, UK

AML Cells and Their Niches

Christian Steidl, University of British Columbia, Canada

Microenvironment and Genomics in B Cell Lymphoma

Short Talk Chosen from Abstracts

19:00—20:00

Social Hour with Lite Bites

19:30—22:00

Poster Session 1

07:00—08:00

Breakfast

Summit Gallery

08:00—11:00

Tumorigenesis

Registered attendees can view abstracts sending on 02/06/2019

Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.

Connie J. Eaves, British Columbia Cancer Agency, Canada

Barcoding to Analyze de novo Generated and Established Human Breast Cancers

Richard J. Gilbertson, St. Jude Children's Research Hospital, USA

Mapping the Origins of Cancer in Multi-Organ Systems

Hanno Glimm, National Center for Tumor Diseases, Germany

Stem Cell Kinetics in Gastrointestinal Cancers

Emmanuelle Passegué, University of California, San Francisco, USA

Mechanisms Controlling Hematopoietic Stem Cell Functions During Normal Hematopoiesis and Hematological Malignancies

Short Talk(s) Chosen from Abstracts

09:20—09:40

Coffee Break

11:00—13:00

Poster Setup

13:00—22:00

Poster Viewing

14:30—16:30

Workshop

Short Talks Chosen from Abstracts

16:30—17:00

Coffee Available

17:00—19:00

Disregulation of Stem/Developmental Pathways

Registered attendees can view abstracts sending on 02/06/2019

Exploration of the role of developmental pathways (eg. Notch, Wnt, Hippo, BMP, RSPO) in CSC biology.

Stefano Piccolo, University of Padua, Italy

Yap/Taz Regulation in Stem Cells and Cancer: Hippo Signaling

Jon C. Aster, Brigham and Women's Hospital, USA

The Role of Notch in Stem Cells and Cancer

Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany

Mechanisms Influencing Intestinal Tumorigenesis

Short Talk Chosen from Abstracts

19:00—20:00

Social Hour with Lite Bites

No registration fees are used to fund alcohol served at this function.

19:30—22:00

Poster Session 2

07:00—08:00

Breakfast

Summit Gallery

08:00—11:00

Understanding Tumor Heterogeneity

Registered attendees can view abstracts sending on 02/06/2019

EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.

Michael F. Clarke, Stanford University, USA

Regulation of Self-Renewal in Cancer

Dean G. Tang, University of Texas MD Anderson Cancer Center, USA

Prostate Cancer Stem Cells: Molecular Understanding and Clinical Implications

Samuel Aparicio, University of British Columbia, Canada

Genomic and Clonal Analysis of Breast Cancer

Catherine A. O'Brien, University Health network, Canada

Regulation of Self-Renewal in Colon Cancer Stem Cells

Short Talk(s) Chosen from Abstracts

09:20—09:40

Coffee Break

11:00—13:00

Poster Setup

13:00—22:00

Poster Viewing

17:00—19:00

Emerging Targets

Registered attendees can view abstracts sending on 02/06/2019

New therapeutic opportunities to target CSCs.

Tak W. Mak, Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital, University Health Network, Canada

Targeting Metabolic Signaling of CSCs

Jeffrey Settleman, Genentech, Inc., USA

Epigenetics and ALDH

Tessa L. Holyoake, University of Glasgow, UK

CML - Aiming for Cure

Short Talk Chosen from Abstracts

19:00—20:00

Social Hour with Lite Bites

No registration fees are used to fund alcohol served at this function.

19:30—22:00

Poster Session 3

07:00—08:00

Breakfast

Summit Gallery

08:00—10:15

Targeting Cancer Stem Cells: Trials and Translation

Registered attendees can view abstracts sending on 02/06/2019

Therapeutic strategies for targeting CSC in the clinic.

Austin Gurney, OncoMed Pharmaceuticals, Inc., USA

Therapeutic Agents Targeting Notch and Wnt

Jonathan A. Pachter, Verastem, USA

Targeting Cancer Stem Cells with Selective Inhibitors of FAK and PI3K/mTOR

Feng Cong, Novartis Institutes for BioMedical Research, USA

B-Catenin Inhibitors

Short Talk(s) Chosen from Abstracts

09:20—09:40

Coffee Break

10:15—11:15

Keynote Address

Registered attendees can view abstracts sending on 02/06/2019

Hans C. Clevers, Hubrecht Institute, Netherlands

16:30—17:00

Coffee Available

17:00—18:45

New Horizons

Registered attendees can view abstracts sending on 02/06/2019

CSC metabolism, ROS involvement-control, epigenetics and miRNA.

Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA

Metastasis and Tumorigenesis by Melanoma Cells

Huiping Liu, Case Western Reserve University, USA

MicroRNAs Regulating Breast Cancer Stem Cells and Metastasis

18:45—19:00

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

19:00—20:00

Social Hour with Lite Bites

No registration fees are used to fund alcohol served at this function.

20:00—23:00

Entertainment

Departure